Medicare Drug Price Negotiation Program
What pharmacies need to know
The Medicare Drug Price Negotiation Program (MDPNP) is a part of the Inflation Reduction Act (IRA) that sets maximum prices for 10 Medicare Part D-covered drugs for 2026, 15 drugs for 2027, and more drugs (including Part B drugs) beginning in 2028. This program will have significant impacts on pharmacy reimbursement and cash flow models.
Pharmacies are not required by CMS to dispense MDPNP drugs, but individual PBM network agreements may require their dispensing.
It is critical that pharmacies read their PBM contracts closely to ensure compliance. Many PBMs are also requiring enrollment into the Medicare Transaction Facilitator (MTF). For more information, click here.
Looking for information about the Medicare Prescription Payment Plan (also part of the IRA)? Check out this
awesome summary from our friends at the Pharmacy Society of Wisconsin!
Pharmacy Resources
Make sure your pharmacy is ready to meet the requirements of the MDPNP, including enrolling in an MTF!
- CMS Pharmacy Resource Page
- CMS Pharmacy FAQs
- MTF Enrollment Webinar
- Beacon - visibility into rebate status and good faith resolution tools
MDPNP Drugs and Negotiated Prices
CMS has provided a list of NDCs that are part of the program, as well as their negotiated prices
Manufacturer Agreements
CMS has provided the list of manufacturers who will be participating in the MDPNP
- 2026 Reimbursement Plans (download, created by NCPA & ASCP)
- 2026 Manufacturers (CMS)
- 2027 Manufacturers (CMS)

